The Phylogenetic Handbook: A Practical Approach to Phylogenetic Analysis and Hypothesis Testing

The Phylogenetic Handbook is a broad, hands on guide to theory and practice of nucleotide and protein phylogenetic analysis. This second edition includes six new chapters, covering topics such as Bayesian inference, tree topology testing and the impact of recombination on phylogenies, as well as a detailed section on molecular adaptation. The book has a stronger focus on hypothesis testing than the previous edition, with more extensive discussions on recombination analysis, detecting molecular adaptation and genealogy-based population genetics. Many chapters include elaborate practical sections, which have been updated to introduce the reader to the most recent versions of sequence analysis and phylogeny software, including BLAST, FastA, Clustal, T-coffee, Muscle, DAMBE, Tree-puzzle, Phylip, MEGA, PAUP*, IQPNNI, CONSEL, ModelTest, Prottest, PAML, HYPHY, MrBayes, BEAST, LAMARC, SplitsTree, and RDP. Many analysis tools are described by their original authors, resulting in clear explanations that constitute an ideal teaching guide for advanced-level undergraduate and graduate students.

About the Author

Philippe Lemey is a FWO postdoctoral researcher at the Rega Institute, Katholieke Universiteit Leuven, Belgium, where he completed his PhD in Medical Sciences. He has been an EMBO fellow and a Marie-Curie fellow in the Evolutionary Biology Group at the Department of Zoology, University of Oxford. His research focuses on molecular evolution of viruses by integrating molecular biology and computational approaches.

Marco Salemi is a postdoctoral scientist in the Medical Faculty at the Katholieke Universiteit, Belgium. He currently holds a research position at the University of California, Irvine, where he works on epidemiological virology and phylogenetic analysis, focusing on the molecular epidemiology of human pathogenic viruses, such as HIV and HCV. He is supported by the Fund for Scientific Research - Flanders, Belgium.

Anne-Mieke Vandamme is a Full Professor in the Medical Faculty at the Katholieke Universiteit, Belgium, working in the field of clinical and epidemiological virology. Her laboratory investigates treatment responses in HIV-infected patients and is respected for its scientific and clinical contributions on virus-drug resistance. Her laboratory also studies the evolution and molecular epidemiology of human viruses such as HIV and HTLV.